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Mounjaro is a prescription medication used to treat type 2 diabetes. Its generic name is semaglutide. It belongs to a class of medications called glucagon-like peptide 1 (GLP-1RA) receptor agonists.
Mounjaro mimics the effects of a hormone called glucagon-like peptide 1 (GLP-1) in the body. GLP-1 is produced naturally in the intestines and helps regulate blood sugar levels. By activating GLP-1 receptors, Mounjaro helps stimulate insulin release from the pancreas, reduce glucose production in the liver, and slow gastric emptying. These measures help reduce blood sugar levels in people with type 2 diabetes.
The medication is usually used in combination with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It is available as an injection once a week and is administered subcutaneously (under the skin).
In clinical studies, Mounjaro has been shown to effectively lower blood sugar levels, reduce body weight, and improve cardiovascular outcomes. It has also been associated with a lower risk of hypoglycemia (low blood sugar) compared to other diabetes medications.
Results from the SUSTAIN-6 trial showed that Mounjaro significantly reduced the risk of major adverse cardiovascular events (MACE), including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke. The study found that Mounjaro reduced the risk of MACE by 26% compared to placebo over a median follow-up of 2.1 years.
In addition to reducing the risk of MACE, Mounjaro also demonstrated benefits in other cardiovascular outcomes. It significantly reduced the risk of cardiovascular death by 39% compared to placebo. Additionally, Mounjaro was associated with a 51% lower risk of all-cause mortality (death from any cause) compared to placebo.
It's worth noting that while Mounjaro has shown cardiovascular benefits in clinical trial, it's always important to discuss the risks and benefits of a medication with a healthcare professional. They can provide individualized advice based on a person's specific medical history and needs.
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